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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP2CA All Species: 59.7
Human Site: S212 Identified Species: 87.56
UniProt: P67775 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P67775 NP_002706.1 309 35594 S212 D R G G W G I S P R G A G Y T
Chimpanzee Pan troglodytes XP_527011 309 35630 S212 D R G G W G I S P R V A G Y T
Rhesus Macaque Macaca mulatta XP_001084083 286 32771 H191 D R L Q E V P H E G P M C D L
Dog Lupus familis XP_858531 311 35711 S214 D R G G W G I S P R G A G Y T
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus P63331 309 35590 S212 D R G G W G I S P R G A G Y T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512852 302 34248 S205 D R G G W G I S P R G A G Y T
Chicken Gallus gallus P48463 309 35545 S212 D R G G W G I S P R G A G Y T
Frog Xenopus laevis Q6IP91 307 35104 S209 D T T G W G V S P R G A G Y L
Zebra Danio Brachydanio rerio A8WGP3 311 35438 S213 D T T G W G V S P R G A G Y L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23696 309 35450 S212 D R G G W G I S P R G A G Y T
Honey Bee Apis mellifera XP_623105 309 35425 S212 D R G G W G I S P R G A G Y T
Nematode Worm Caenorhab. elegans Q9XW79 333 37341 S235 G N V G W G L S P R G A G Y L
Sea Urchin Strong. purpuratus XP_780423 308 35412 S211 D R G G W G I S P R G A G Y T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q07100 313 35814 S216 D R C G W G I S P R G A G Y T
Baker's Yeast Sacchar. cerevisiae P23595 377 43028 S280 D R G G W G I S P R G A G F T
Red Bread Mold Neurospora crassa P48580 327 37273 S230 D R C G W G I S P R G A G Y T
Conservation
Percent
Protein Identity: 100 99 89.9 96.7 N.A. N.A. 99.6 N.A. 90.9 98 66 64.6 N.A. 93.8 96.1 59.1 93.5
Protein Similarity: 100 99 91.9 98.7 N.A. N.A. 100 N.A. 93.1 99 81.5 81 N.A. 98.7 98 74.7 96.7
P-Site Identity: 100 93.3 13.3 100 N.A. N.A. 100 N.A. 100 100 73.3 73.3 N.A. 100 100 66.6 100
P-Site Similarity: 100 93.3 13.3 100 N.A. N.A. 100 N.A. 100 100 80 80 N.A. 100 100 73.3 100
Percent
Protein Identity: N.A. N.A. N.A. 78.5 62.6 81.3
Protein Similarity: N.A. N.A. N.A. 87.2 71.8 86.8
P-Site Identity: N.A. N.A. N.A. 93.3 93.3 93.3
P-Site Similarity: N.A. N.A. N.A. 93.3 100 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 94 0 0 0 % A
% Cys: 0 0 13 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 94 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % D
% Glu: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 7 0 63 94 0 94 0 0 0 7 88 0 94 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 75 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 7 0 0 0 7 0 0 0 0 0 0 0 25 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 7 0 94 0 7 0 0 0 0 % P
% Gln: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 82 0 0 0 0 0 0 0 94 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 94 0 0 0 0 0 0 0 % S
% Thr: 0 13 13 0 0 0 0 0 0 0 0 0 0 0 75 % T
% Val: 0 0 7 0 0 7 13 0 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 94 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 88 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _